The year is 1888 and a madman is terrorizing the East End of London. But Doctor Varanus Shashavani has far more pressing concerns to worry about than a lunatic in Whitechapel. Her charitable hospital is under siege by gang lords, her English cousins are threatening to steal her inheritance, and her best friend has become obsessed with Gothic novels. To make matters worse, her son Friedrich is associating with an American who talks endlessly of wellness and yoghurt, while her bodyguard is pestering her to return home to Georgia, half a world away. It seems that everyone—friends, enemies, and "Saucy Jack" alike—have conspired to interrupt her work.

But Varanus did not obtain immortality just to have mad killers and distant relations get in the way of scientific progress. Though supernatural conspiracies and all-too-human monsters confront her at every turn, Varanus will stand firm against all odds. After all, she is accustomed to fighting for what is rightfully hers.