My Ántonia, first published 1918, is one of Willa Cather's greatest works. It is the last novel in the Prairie trilogy, preceded by O Pioneers! and The Song of the Lark.

My Ántonia tells the stories of several immigrant families who move out to rural Nebraska to start new lives in America, with a particular focus on a Bohemian family, the Shimerdas, whose eldest daughter is named Ántonia. The book's narrator, Jim Burden, arrives in the fictional town of Black Hawk, Nebraska, on the same train as the Shimerdas, as he goes to live with his grandparents after his parents have died. Jim develops strong feelings for Ántonia, something between a crush and a filial bond, and the reader views Ántonia's life, including its attendant struggles and triumphs, through that lens.