Siblings Jonah and Nell Talbot used to be inseparable, but ever since Jonah suddenly blew town twelve years ago, they couldn't be more distant. Now, in the wake of Jonah's divorce, they embark on a cross-country road trip back to their hometown of Albuquerque, hoping to mend their broken relationship along the way. But when a strange accident befalls Nell at an abandoned industrial site somewhere in the Nevada desert, she begins experiencing ghastly visions and exhibiting terrifying, otherworldly symptoms. As their journey through the desolate American Southwest reveals the grotesque change happening within his sister, one thing becomes clear to Jonah: It's not only Nell in there anymore. Pursued by a mysterious stranger who knows far more about Nell's worsening condition than they let on, the siblings race to find a way to help Nell and escape the desert before they're met with a violent, bloody end. But there are far worse things lurking in the desert ahead...some of them just beneath the skin.