What turns out to be one of the most interesting cases of the great detective's career begins when a country doctor visits Holmes and Watson in London. He brings with him the legend of the hound and news of the sudden death of Sir Charles Baskerville. Sir Charles' heir, Henry, is arriving from America and the doctor is afraid for the young man's life. Holmes despatches Dr Watson to accompany them back to the dark and somber estate in the Devon moor.

With peril at every turn and a murderous escaped convict at large, the mystery depends. Is the ancient legend true, or is the hideous creature merely a part of a sinister conspiracy whose origins are all too diabolically human?