When the Blue Blur and Rad Red team-up, the bad guys better watch out! The spotlight's on the guardian of Angel Island, Knuckles the Echinda! Tasked with protecting his floating home and the powerful Master Emerald, Knuckles has encountered the worst of the worst: Rough & Tumble, Neo Metal Sonic, and even Dr. Eggman! With nothing but his powerful fists—and maybe some help from the likes of Sonic the Hedgehog, Miles "Tails" Prower, and Blaze the Cat—Knuckles has beat them all back to protect not just his island, but the whole world! Sonic the Hedgehog: Knuckles' Greatest Hits contains Sonic the Hedgehog #3, Sonic the Hedgehog #10, Sonic the Hedgehog #11, Sonic the Hedgehog Free Comic Book Day 2022, and "Guardians" from Sonic the Hedgehog Annual 2022 by contributors Ian Flynn, Jennifer Hernandez, Tracy Yardley, Evan Stanley, Bracardi Curry, and Adam Bryce Thomas!