Authoritative information and practical advice from the nation's cancer experts about adrenocortical carcinoma includes official medical data on signs, symptoms, treatment options, drugs, chemotherapy, staging, biology, prognosis, and survival, with a complete glossary of technical medical terms and current references. Starting with the basics, and advancing to detailed patient-oriented and physician-quality information, this comprehensive in-depth compilation gives empowered patients, families, caregivers, nurses, and physicians the knowledge they need to understand the diagnosis and treatment of adrenocortical carcinoma.

Adrenocortical carcinoma is a rare tumor that affects only 1 to 2 persons per one million population. It usually occurs in adults, and the median age at diagnosis is 44 years. Although adrenal carcinoma is potentially curable at early stages, only 30% of these malignancies are confined to the adrenal gland at the time of diagnosis. Radical surgical excision is the treatment of choice for patients with localized malignancies and remains the only method by which long-term disease-free survival may be achieved. Overall 5-year survival for tumors resected for cure is approximately 40%.

Retrospective studies have identified two important prognostic factors: completeness of resection and stage of disease. Patients without evidence of invasion into local tissues or spread to lymph nodes have an improved prognosis. The role of DNA ploidy as a prognostic indicator is controversial, with some studies, such as ECOG-1879 for example, showing correlation between aneuploidy and prognosis, and other studies showing no correlation.

Comprehensive data on clinical trials related to adrenocortical carcinoma is included - with information on intervention, sponsor, gender, age group, trial phase, number of enrolled patients, funding source, study type, study design, NCT identification number and other IDs, first received date, start date, completion date, primary completion date, last updated date, last verified date, associated acronym, and outcome measures.

Extensive supplements, with chapters gathered from our Cancer Toolkit series and other reports, cover a broad range of cancer topics useful to cancer patients. This edition includes our exclusive Guide to Leading Medical Websites with updated links to 81 of the best sites for medical information, which let you quickly check for updates from the government and the best commercial portals, news sites, reference/textbook/non-commercial portals, and health organizations. Supplemental coverage includes:

Levels of Evidence for Cancer Treatment Studies

Glossary of Clinical Trial Terms

Clinical Trials Background Information and In-Depth Program

Clinical Trials at NIH

How To Find A Cancer Treatment Trial: A Ten-Step Guide

Taking Part in Cancer Treatment Research Studies

Access to Investigational Drugs

Clinical Trials Conducted by the National Cancer Institute's Center for Cancer Research at the National Institutes of Health Clinical Center

Taking Time: Support for People with Cancer

Facing Forward - Life After Cancer Treatment

Chemotherapy and You

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