On their way to Colorado, Ruff and Dixie Ballou drive their horses through New Mexico. Their intention to quietly drive the horses on through goes well until they find themselves inadvertently involved in a shootout with four outlaws who robbed the banks of a small town in New Mexico. An edgy sheriff and angry townspeople get the Ballou's involved in a situation they would be more happy to do without. Even more so when they are arrested by the sheriff as robbery suspects.