During the Depression the ebullient American entrepreneur Charles Flanagan assembles 2,000 runners from all corners of the earth, to run from Los Angeles to New York for prize-money of $150,000. Flanagan's Trans-America runners face 3,000 miles, across the Mojave desert and the frozen Rockies, running a daily average of 50 miles for three months. The American sports establishment, however, is desperate to crush what it sees as a professional challenge to the 1932 Los Angeles Olympics. Every day is therefore a struggle for survival, for Flanagan himself as well as the runners. Flanagan's Run is an epic tale, and a testimony to the strength of the human spirit.