Most will run, but the brave will fight...

A deadly virus is sweeping through America's cities, pitting the worst humanity has to offer against its best warriors and scientists in a race against extinction. The virus doesn't just kill—it transforms and creates monsters of men and women called Variants.

New York firefighter Meg Pratt is among those trapped in New York City. Together with her fellow rescue workers and the scattered elements of America's front-line military fighters, Meg fights to survive and hope to save civilians from the coming apocalypse.

Across the city, Marine Corps washout Jed Welch is on his own path to survival, and it intersects with Meg and her ragtag group of survivors. If they are lucky, they will see the help they need emerge from within, just as everything around them is coming to an end.