Mitch Kessler, gargoyle, is back, along with his girlfriend, Callie, a former gender shifter, his best friend, Joe Chambers, a spinning top, and Neil, their rock-man sometime ally.

Mitch and Joe help the police force of Independence, Oregon, fight crime, but their efforts go totally unreported by everyone. While that bothers Mitch, what bothers him more is his best friend's rapid aging. Joe is dying, and no one seems to know how to stop it.

Except one person—Harmon Carson, an army general. Carson promises Mitch, Neil, and Joe, a cure for their condition, contingent on them finding a renegade scientist who carries the secret with him. The four volunteer, but soon find out that Carson has his own agenda going on—and it is not a friendly one.

With time running out, Mitch has to find the scientist who may be able to help them, assist another mutant called Niles, rescue his girlfriend, and fight the hordes of the unholy that Carson calls forth. Once again, the Outcasts are the underdogs, and only time will tell if they can prevail.