In 1587, a group of about 115 English settlers arrived on Roanoke Island near North Carolina. They were there to establish an English colony. Later that year, the colony's leader left the island to get supplies. His return trip was delayed. When he finally returned in 1590, the colony and its settlers were gone. What happened to the settlers? Explore the theories behind their disappearance and why it has become one of history's greatest mysteries.