Down the eastern slopes of the Rockies, out upon the Great Plains, and into the heart of Blackfeet country flows the Two Medicine River. To this wild and beautiful land come a pair of young wanderers, half-breeds born of two worlds... but belonging to neither. Marie Therese de Paris - driven by the ancestral fires in her spirit - sets out on a vision quest, hoping to save the Blackfeet from their cruel fate. Peter Kipp, bold and ambitious, chooses to follow his father into the American Fur Company, determined to prove himself in the white man's world. Bound by love, torn by their loyalties, they share a single destiny about to unfold on the Two Medicine River...