She's a cop turned defense lawyer; her husband a research scientist. She lives in a half-million-dollar home. Yet on this night, Andrea Wilson—a woman who seemingly has everything—awakens to a living nightmare. Her husband Paul is dead, she's covered in his blood, and the police are banging on her door. Andrea doesn't remember what happened, but she knows how it looks. With just a split second to make a choice, Andrea decides to run, and in doing so risks everything in an attempt to clear her name.

Enter Detective Mike Coletti. He and Andrea shared a relationship once; now all they share is the chase. As Andrea races to prove her innocence and Coletti struggles to track her down, each uncovers clues about the mystery of Paul's death, and along the way, Andrea finds the answer to the biggest question of all: is her husband actually still alive?