At first sight there is no connection between the deaths of three agents in West Africa and the fact that one of Dr. Palfrey's friends has suddenly lost a great deal of weight. However, behind both is an organisation using a drug that puts world domination within the reach of a few ruthless individuals. Blackmail ensues and Palfrey must deal with what could be the worst situation he has ever faced; an overwhelming and brutal conspiracy that threatens the lives of millions of people.