This book presents the proceedings of 2nd EAI International Conference on Smart Technology (MTYMEX), which took place April 27th, 2021, online and in Monterrey, Mexico. MTYMEX is an international conference aimed at demonstrating the potential of new applications for the Internet in the future. The authors offer perspectives on research on smart technologies in society, including the results of research projects on virtual reality, blockchain, artificial intelligence, and smart cities. The book offers examples of applications with smart technologies in different knowledge areas. The conference brings together the academic, research and private sectors working on applications and smart devices for e-health and smart cities.