In these six adventures, Holmes solves cases in alternate universes and alongside famous historical and fictional figures. In the title story, Watson is slandered by mysterious forces who spread the rumor that the good doctor pushed Holmes off of Reichenbach Falls. In other cases, Holmes solves a real-life murder aboard a train; partners with G.K. Chesterton's Father Brown in a murder case; helps the crusading lawyer Grace Quackenbos Humiston (affectionately nicknamed "Mrs. Sherlock Holmes"); seeks out someone capable of filling his brother Mycroft's shoes; and investigates a plagiarism lawsuit involving H.G. Wells. The game is afoot!