Sanctuary is a novel by the American author William Faulkner about the rape and abduction of a well-bred Mississippi college girl, Temple Drake, during the Prohibition era. It is considered one of his more controversial works, given its theme of rape. First published in 1931, it was Faulkner's commercial and critical breakthrough, establishing his literary reputation. It is said Faulkner claimed it was a "potboiler", written purely for profit, but this has been debated by scholars and Faulkner's own friends.

The novel provided the basis for the films The Story of Temple Drake (1933) and Sanctuary (1961).